TPA provides in vivo measurement of the pH of the gastro intestinal tract.
TPA provides custom processing of 1-2 mm tissue organoids for paraffin embedding, sectioning and immunostaining.
Non-routine bone decalcification with EDTA allows for immunostaining of bone tissue section with improved morphology over acid decalcification.
Glycol methacrylate (GMA) processing, embedding, sectioning and staining is used for ultra-thin (1-2 µ) tissue sections.

The arrows show cytoplasmic vacuols.

The arrows show osmium tetraoxide stained fat droplets.
Recently a 3D culture has been developed that allows the reorganization of rat primary testicular cells into organoids with a functioning blood-testis barrier, as well as the establishment and maintenance of germ cells. This technique is successfully used by NCTR investigators. TPA provides support for histological evaluation as well as immunohistochemical identification of types of cells and structures in the organoids.

Rat testicular organoid (H&E), x4

A curved spine is a clinical sign of Microsporidiosis (xenomas).

The arrow shows Microsporidiosis (xenomas) in the spinal cord of a ZebraFish.

The arrow shows Microsporidiosis (xenomas) in the spinal cord of a ZebraFish.

TPA has a number of distillation units in use to recycling xylene, alcohol, methanol, formalin and acetone. This not only saves on the initial reagent purchases, but also saves time, waste disposal costs; also obviating the need to store large volumes of hazardous chemicals before use and disposal.